Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations

Gut microbiota protects against gastrointestinal tumorigenesis caused by epithelial injury.

Inflammation is a critical player in the development of both colitis-associated and sporadic colon cancers. Several studies suggest that the microbiota contribute to inflammation and tumorigenesis; however, studies to understand the role of the microbiota in colon tumor development in germ-free (GF) mice are limited. We therefore studied the effects of the microbiota on the development of infla...

Gut Microbiota and Inflammation

Systemic and local inflammation in relation to the resident microbiota of the human gastro-intestinal (GI) tract and administration of probiotics are the main themes of the present review. The dominating taxa of the human GI tract and their potential for aggravating or suppressing inflammation are described. The review focuses on human trials with probiotics and does not include in vitro studie...

Relationship between gut microbiota and type 2 diabetes

Diabetes is the most common endocrine disease following the spread of metabolic diseases worldwide. Diabetes is also the fifth leading cause of death in the world. Patients with type 2 diabetes account for about 90% of people with diabetes. Studies over the past years have shown a significant association between intestinal microbiota, intestinal dysbiosis, and metabolic syndrome. Changes in the...

Gut Microbiota and Neuropsychiatric Disorders

Microenvironment and Immunology Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury

Inflammation is a critical player in the development of both colitis-associated and sporadic colon cancers. Several studies suggest that the microbiota contribute to inflammation and tumorigenesis; however, studies to understand the role of the microbiota in colon tumor development in germ-free (GF) mice are limited. We therefore studied the effects of the microbiota on the development of infla...